DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma

Dipeptidyl peptidase (DPP) 9, DPP8, DPP4 and fibroblast activation protein (FAP) are the four enzymatically active members of S9b protease family. Associations DPP9 with human liver cancer, exonic single nucleotide polymorphisms (SNPs) in loss function (LoF) variants have not been explored. Human genomic databases, including The Cancer Genome Atlas (TCGA), were interrogated to identify LoF associated cancers. Survival gene signature analyses performed on hepatocellular carcinoma (HCC) data. We found that DPP8 intolerant variants. most often uterine lung carcinoma. All DPP4-like genes overexpressed tumors their joint high expression was poor survival HCC. Increased obesity HCC patients. High positively correlated overexpression DPP4, very Enriched pathways analysis these featured Toll-like receptor SUMOylation pathways. This comprehensive data mining suggests is important for family, particularly DPP9, pathogenesis